Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs
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چکیده
منابع مشابه
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs.
We have synthesized derivatives of dephostatin, a protein tyrosine phosphatase (PTPase) inhibitor, to study the structure-activity relationships of this inhibitor. Inactive analogs revealed some insight into structural requirements or PTPase inhibitory activity of dephostatin. Both a nitroso group and phenolic hydroxyl groups were found to be essential for the inhibitory activity. Among the dep...
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15 صفحه اولSynthesis and screening of aromatase inhibitory activity of substituted C19 steroidal 17-oxime analogs.
The synthesis and aromatase inhibitory activity of androst-4-en-, androst-5-en-, 1β,2β-epoxy- and/or androsta-4,6-dien-, 4β,5β-epoxyandrostane-, and 4-substituted androst-4-en-17-oxime derivatives are described. Inhibition activity of synthesized compounds was assessed using aromatase enzyme and [1β-3H]androstenedione as substrate. Most of the compounds displayed similar to or more aromatase in...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2013
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2013.06.012